DES MACROPHAGES INGERENT LES CELLULES CANCEREUSES EN UTILISANT LEUR PROPRE CALRETICULINE EN TANT QUE GUIDE

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专利权人:

THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNVERSITY

发明人:

WEISSMAN, IRVING L.,FENG, MINGYE,VOLKMER, JENS-PETER

申请号：

CA2972913

公开号：

CA2972913A1

申请日:

2016.01.21

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

Therapeutic and diagnostic methods are provided, which methods relate to the induction of expression of calreticulin on phagocytic cells. Specifically, the methods relate to macrophage-mediated programmed cell removal (PrCR), the methods comprising increasing PrCR by contacting a phagocytic cell with a toll-like receptor (TLR) agonist； or down-regulating PrCR by contacting a phagocytic cell with an inhibitor of Bruton's tyrosine kinase (BTK). In some embodiments, an activator of TLR signaling or a BTK agonist is provided in combination with CD47 blockade.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/