The present invention is directed to pharmaceutical compositions, and methods of making such compositions, comprising microparticles containing a weakly basic drug core, a layer of alkaline buffer, and a controlled-release coating. The present invention is also directed to pharmaceutical dosage forms, including orally disintegrating tablets, conventional tablets, and capsules, and methods for their preparation.本發明係關於一種醫藥組合物及製造此等組合物之方法，該等組合物包括含有弱鹼性藥物核、鹼性緩衝劑層、及控制釋放包膜之微粒。本發明亦係關於一種醫藥劑型(包括在口中崩解之錠劑、習用錠劑、及膠囊)及其製備方法。
