PROBLEM TO BE SOLVED: To provide compositions comprising weakly basic drugs and controlled-release dosage forms.SOLUTION: The present invention is directed to pharmaceutical compositions, and methods of making such compositions, comprising microparticles containing a weakly basic drug core, a layer of an alkaline buffer, and a controlled-release coating. The present invention is also directed to pharmaceutical dosage forms, including orally disintegrating tablets, conventional tablets, and capsules, and methods for their preparation.【課題】弱塩基性薬物を含む組成物及び徐放性剤形に関する。【解決手段】本発明は、弱塩基性薬物コアと、アルカリ性緩衝剤の層と、徐放性コーティングとを含有する微粒子を含む医薬組成物、及びかかる組成物の製造方法に関する。本発明はまた、口腔内崩壊錠、従来の錠剤、及びカプセルを含む医薬剤形、並びにその調製方法にも関する。【選択図】図１
