PROBLEM TO BE SOLVED: To provide a skin care preparation that has an excellent production acceleration effect on tight junction constitutional protein and an excellent production acceleration effect on ceramide and can effectively make the prophylaxis and improvement of skin symptoms such as skin chapping, atopic dermatitis, and various infectious diseases and also make the improvement of such change with aging in skin properties as gerontal xeroderma by means of improving the barrier function and moisture-keeping function.SOLUTION: This skin care preparation includes 3-phosphoadenosine 5-phosphosulfate (PAPS) or salts thereof as the effective component.COPYRIGHT: (C)2013,JPO&INPIT【課題】優れたタイトジャンクション構成タンパク質産生促進効果および優れたセラミド産生促進効果を有し、バリア機能および水分保持機能を向上させることにより、荒れ肌、アトピー性皮膚炎、各種感染症などの皮膚症状の予防・改善、および老人性乾皮症などの加齢による皮膚性状の変化の改善を効果的に行うことができる皮膚外用剤の提供。【解決手段】3’-ホスホアデノシン5’-ホスホ硫酸(PAPS)またはその塩を有効成分として含有する皮膚外用剤。【選択図】なし
