PROBLEM TO BE SOLVED: To provide a VEGF production promoter, an agent for improving the nature of hair, and an external preparation for a skin, which have a VEGF production promoting activity and can be used as a pharmaceutical product, a cosmetic or a food, or a raw material of these products.SOLUTION: The VEGF production promoter, the agent for improving the nature of hair, or the external preparation for a skin contains, as an active ingredient, a diacylated dihydropyranocumarin represented by general formula (1) or (2). In the formulae, R1 and R2 are identical to or different from each other and represent an acetyl group, an angeloyl group or a senecioyl group.COPYRIGHT: (C)2012,JPO&INPIT【課題】VEGF産生促進作用を有し、医薬品、化粧品若しくは食品、又はそれらの素材となり得る、VEGF産生促進剤、髪質改善剤、及び皮膚外用剤の提供。【解決手段】下記一般式(1)又は(2):〔式中、R1及びR2は、同一又は異なって、アセチル基、アンゲロイル基又はセネシオイル基を示す。〕で表されるジアシル化ジヒドロピラノクマリンを有効成分とするVEGF産生促進剤、髪質改善剤、皮膚外用剤。【選択図】なし
