An angioplasty device may comprise a catheter, a balloon disposed on the catheter, and a scaffold disposed over the balloon. The scaffold may comprise an electrospun polymer fiber and an agent dispersed within the fiber. A method of making such an angioplasty device may comprise obtaining a catheter having a balloon disposed on it, contracting the balloon, and electrospinning a polymer solution onto the surface of the catheter having the balloon, thereby forming a scaffold disposed over the balloon. The polymer solution may comprise a polymer, a solvent, and an agent. A method of performing an angioplasty procedure may comprise inserting such an angioplasty device into a blood vessel, placing the angioplasty device near a lesion within the blood vessel, expanding the balloon, thereby contacting the lesion with the scaffold, contracting the balloon, and removing the angioplasty device from the blood vessel.
