NOVEL CYTOTOXIC AGENTS THAT PREFERENTIALLY TARGET LEUKEMIA INHIBITORY FACTOR (LIF) FOR THE TREATMENT OF MALIGNANCIES AND AS NEW CONTRACEPTIVE AGENTS

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专利权人:

EVESTRA; INC.

发明人:

NAIR, HAREESH,SANTHAMMA, BINDU,NICKISCH, KLAUS

申请号：

CA2981173

公开号：

CA2981173A1

申请日:

2016.03.22

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

Described herein are new anti-cancer compounds and methods of using such compounds, acting through a new mechanism of action by simultaneous inhibition of leukemia inhibitory factor (LIF) and MDM2. In one embodiment, a cytotoxic compound has the structure (I) or (II). In an embodiment, a method of treating cancer in a subject comprising administering to a subject a medicament comprising an effective amount of a cytotoxic small molecule compound that inhibits leukemia inhibitory factor or leukemia inhibitory factor receptor.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/