PROBLEM TO BE SOLVED: To provide an endoscope system easy to use in observation or diagnosis and also to provide a method of driving such an endoscope system.SOLUTION: An endoscope system 10 comprises: an endoscope 12 including a side-viewing observation unit 42 which has a field of view in a lateral direction of an insertion part 12a to be inserted into an observation object and a second protruding portion 32 which protrudes from the insertion part 12a and forms a blind spot in the field of view of the side-viewing observation unit 42; an image acquisition unit 97 which acquires a side-viewing observation image 112 by using the side-viewing observation unit 42; a monitor 18 which displays the side-viewing observation image 112; and a display control unit 98 which hides, from the side-viewing observation image 112, at least a portion of the blind spot where the second protruding portion 32 is captured, and displays the side-viewing observation image 112 on the monitor 18.SELECTED DRAWING: Figure 6【課題】観察または診断等において使用しやすい内視鏡システム及び内視鏡システムの駆動方法を提供する。【解決手段】内視鏡システム10は、観察対象に挿入する挿入部12aの側面方向に視野を有する側視観察部42と、挿入部12aから突出し、側視観察部42の視野に死角を形成する第2突出部32と、を有する内視鏡12と、側視観察部42を用いて側視観察画像112を取得する画像取得部97と、側視観察画像112を表示するモニタ18と、側視観察画像112のうち第2突出部32が写る死角の少なくとも一部を非表示化して、モニタ18に側視観察画像112を表示する表示制御部98と、を備える。【選択図】図6