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Inhibitor compounds and cancer treatment methods
专利权人:
Wayne R. Danter
发明人:
Wayne R. Danter
申请号:
US12505295
公开号:
US08138191B2
申请日:
2009.07.17
申请国别(地区):
US
年份:
2012
代理人:
摘要:
A synergistically effective combination of an anti-cancer agent and a therapeutic compound, such as an mTOR-Rictor complex inhibitor, a Serine 473 phosphorylation inhibitor, an AKT2 inhibitor, or a combination thereof, for use in the treatment of cancer, and methods and uses thereof. Also included are methods and uses of a thiosemicarbazone for treating a cancer in a mammal in need thereof characterized by over-expression of RAS, by an EGFR mutation, and/or by over-expression of AKT2.
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