The present invention relates to a skin biopsy device (100) which performs biopsy cutaneously and subcutaneously. With the inventive biopsy device (100), the tissue wanted to be performed biopsy is enabled to be removed with vacuum. Also the base of the tissue wanted to be performed biopsy is cut without harming the adjacent tissues. The biopsy device (100) is comprised of at least one body (1) which enables the tissue piece wanted to be performed biopsy to be pulled with vacuum and a housing (2) having a mechanism which enables the tissue piece to be cut by being fixed on the body (1).