<；p>；A Compound represented by the following general formula (1), salts thereof or hydrates of the foregoing is a novel compound useful for treatment and/or prevention of diseases associated with thrombus formation, and which is safer with suitable physicochemical stability. [wherein R<；SUP>；1a<；/SUP>；, R<；SUP>；1b<；/SUP>；, R<；SUP>；1c <；/SUP>；and R<；SUP>；1d <；/SUP>；each independently represent hydrogen, etc.； R<；SUP>；2 <；/SUP>；represents optionally substituted phenyl, etc.； R<；SUP>；3 <；/SUP>；represents optionally substituted C6-10 aryl, etc.； and Z<；SUP>；1 <；/SUP>；and Z<；SUP>；2 <；/SUP>；each independently represent hydrogen]<；/p>；[US2008015199A1]
