A controlled substance Intercept system for collecting and detecting levels of one or more controlled substances in the breath of a subject and intercepting electric operation of a device, comprising: a sample capture module; a THC identification module; and an intercept module. The THC identification module sends an electric or optical signal to the intercept module if a level of controlled substance present in a sample captured in the sample capture, module exceeds a set threshold, for use in applications to enable or disable operation of equipment such as motor vehicles and construction equipment, and to enable or disable access to locations where impairment would pose a hazard, such as air or marine traffic control centers.