The present invention refers to novel compositions and to methods of using the compositions to enhance the detoxification (e.g., deactivation, metabolism, and/or excretion) of various toxins, harmful substances or other foreign substances and to treat and/or prevent diseases or disorders mediated by increased levels of such toxins, harmful substances or other foreign substances. This invention also generally relates to compositions and to methods of using the compositions to maintain and/or increase the levels of glutathione stores and/or other critical components of the Phase 2 processes.