THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;DAVID B. WEINER;MICHELE KUTZLER;ANDREW K. CHOO;JOO-SUNG YANG;JEAN D. BOYER
发明人:
DAVID B. WEINER,MICHELE KUTZLER,ANDREW K. CHOO,JOO-SUNG YANG,JEAN D. BOYER
申请号：
IL17249605
公开号：
IL172496A
申请日:
2005.12.11
申请国别(地区):
IL
年份:
2013
代理人:
摘要：
Fusion proteins and nucleic acid molecules encoding fusion proteins are disclosed. Fusion proteins comprising non-IL-15 signal peptide linked to IL-15 protein sequences and fusion proteins comprising an IgE signal peptide linked to non-IgE protein sequences are disclosed. Vectors comprising such nucleic acid molecules； and to host cells comprising such vectors are disclosed as well as recombinant vaccines and live attenuated pathogens encoding fusion proteins, and methods of using the same, are disclosed. The immunomodulatory effect following delivery of IL-15 and CD40L, with or without immunogens, is disclosed as are various nucleic acid molecules and compositions thereof used for delivering such proteins and methods of using such compositions.
