Claim 1: a compound of the formula (1) or one of its Salts, and is no cr u00b9； r u00b9, r u00b3 and r u2074 are equal to or different from each other and each Lower Rent that can be substituted with one or more substituents selected from the Group comprising halogen - or, - Oh, - alqui Lower, Lower alkyl or halogen - and - nr u2079r u00b9 u2070,H is lower alkyl or Halogen； R u00b2 can be substituted with one or more substituents selected from the group consisting of halogen and R u00b2 Ciano, and can be combined with r u00b9 to form - (ch u2082) u2099 -R u00b2 or can be combined with r u00b3 to form - (ch u2082) u2099 -； n is 2 or 3； r u2075 u00b9 and r u2075 u00b2 are equal to or different from each other and are lower for rent that can be substituted with one or more substituents Selected cycloalkyl Group G, which can be substituted with one or more sust Ituyentes selected from the Group g u00b9, or h, and besides,R u2075 u00b9 and r u2075 u00b2 can be combined with a nitrogen Atom to which they are United to form a cyclic Amine can be substituted with one or more substituents selected from the Group g u00b9； X is a Link, or nr u00b9 u00b9 - - - - - nr u00b9 u00b9 or lower alkyl； r u00b9 u00b9 is H or alkyl r u2076 is lower； Can be replaced with one or more substituents selected from the Group g u2074,Or cycloalkyl which can be substituted with one or more substituents selected from the Group g u00b3, moreover, when X is nr u00b9 u00b9 r u2076 - - - - r u2076,R u2076 and r u00b9 u00b9 can be combined with a nitrogen Atom to which they are United to form a cyclic Amine can be substituted with one or more substituents selected from the Group g u00b3； r u2077 and r u2078 are equal to or different from each other and each Lower Rent that can be Substituted with one or more substituents selected from the Group comprising Halogen, - Oh,- and Halogen or lower alkyl or h； Group g u00b9 g u00b3 include Lower alkyl group and Lower alkyl, halogen, halogen, - Oh, - or lowe
