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HDAC inhibitors
专利权人:
Lixte Biotechnology; Inc.
发明人:
KOVACH, John,JOHNSON, Francis
申请号:
ES08836599
公开号:
ES2628748T3
申请日:
2008.10.01
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound that has the structure ** Formula ** in which n is 3-10; X is C-R11 or N, where R11 is H, OH, SH, F, Cl, SO2R7, NO2, trifluoromethyl, methoxy or CO-R7, wherein R7 is C3-C8 alkyl, alkenyl, alkynyl, cycloalkyl or aryl; Z is R2 is H or NR3R4, wherein R3 and R4 are each independently H, C1-C6 alkyl or C3-C8 cycloalkyl; R5 is OH or SH; R6 is H, OH, F, Cl, SO2R15, NO2, trifluoromethyl, methoxy or CO-R15, wherein R15 is alkyl, alkenyl, alkynyl, C3-C8 cycloalkyl or aryl; R12 is H, OH, SH, F, Cl, SO2R15, NO2, trifluoromethyl, methoxy or CO-R15, wherein R15 is alkyl, alkenyl, alkynyl, C3-C8 cycloalkyl or aryl; and R13 and R14 are each independently H, SH, F, Cl, SO2R15, NO2, trifluoromethyl, methoxy or CO-R15, wherein R15 is alkyl, alkenyl, alkynyl, C3-C8 cycloalkyl or aryl, or a salt of the compound.Un compuesto que tiene la estructura**Fórmula** en la que n es 3-10; X es C-R11 o N, en la que R11 es H, OH, SH, F, Cl, SO2R7, NO2, trifluorometilo, metoxi o CO-R7, en la que R7 es alquilo, alquenilo, alquinilo, cicloalquilo C3-C8 o arilo; Z es R2 es H o NR3R4, en la que R3 y R4 son cada uno independientemente H, alquilo C1-C6 o cicloalquilo C3-C8; R5 es OH o SH; R6 es H, OH, F, Cl, SO2R15, NO2, trifluorometilo, metoxi o CO-R15, en la que R15 es alquilo, alquenilo, alquinilo, cicloalquilo C3-C8 o arilo; R12 es H, OH, SH, F, Cl, SO2R15, NO2, trifluorometilo, metoxi o CO-R15, en la que R15 es alquilo, alquenilo, alquinilo, cicloalquilo C3-C8 o arilo; y R13 y R14 son cada uno independientemente H, SH, F, Cl, SO2R15, NO2, trifluorometilo, metoxi o CO-R15, en la que R15 es alquilo, alquenilo, alquinilo, cicloalquilo C3-C8 o arilo, o una sal del compuesto.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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