Yeo Joon Yoon;Sung Ryeol Park;Je Won Park;Jae Kyung Sohng
发明人:
Yeo Joon Yoon,Sung Ryeol Park,Je Won Park,Jae Kyung Sohng
申请号：
US13642842
公开号：
US09133492B2
申请日:
2010.10.14
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Vectors expressing kanA-kanB-kanK and other kanamycin production-related genes, Streptomyces<；i/>； species recombinant bacteria transformed with the vectors, a method of producing kanamycin antibiotics by the bacteria, and a new kanamycin compound produced by the bacterium are provided. With the use of the recombinant bacteria of the present invention, the direct fermentative biosynthesis of amikacin and tobramycin as semi-synthetic kanamycins is possible, and the yield of kanamycin B as a precursor of the semi-synthetic kanamycin is improved.
