Yeo Joon Yoon,Sung Ryeol Park,Je Won Park,Jae Kyung Sohng
申请号：
US14831519
公开号：
US10337044B2
申请日:
2015.08.20
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Vectors expressing kanA-kanB-kanK and other kanamycin production-related genes, Streptomyces species recombinant bacteria transformed with the vectors, a method of producing kanamycin antibiotics by the bacteria, and a new kanamycin compound produced by the bacterium are provided. With the use of the recombinant bacteria of the present invention, the direct fermentative biosynthesis of amikacin and tobramycin as semi-synthetic kanamycins is possible, and the yield of kanamycin B as a precursor of the semi-synthetic kanamycin is improved.
