The present invention relates to a pharmaceutical composition for preventing, alleviating or treating reflux esophagitis or skin diseases including the fermented Eastern prickly pear. The pharmaceutical composition or food composition for reflux esophagitis or treatment, prevention or alleviation of skin diseases has the fermented Eastern prickly pear and accordingly effects of treating, preventing or alleviating skin disease in particular pimples or atopic dermatitis.본 발명은 천년초 발효물을 함유하는 역류성 식도염 또는 피부 질환의 치료, 예방 또는 완화용 의약 조성물에 관한 것이다.