The present invention relates to a pharmaceutical composition for treating, preventing, or alleviating reflux esophagitis or skin diseases, containing fermented eastern prickly pear. The fermented eastern prickly pear is produced by fermenting eastern prickly pear with yeast or aspergillus.COPYRIGHT KIPO 2015본 발명은 천년초 발효물을 함유하는 역류성 식도염 또는 피부 질환의 치료, 예방 또는 완화용 의약 조성물에 관한 것이다.