BUSCHMANN, Nicole,FAIRHURST, Robin Alec,FURET, Pascal,KNÖPFEL, Thomas,LEBLANC, Catherine,MAH, Robert,NIMSGERN, Pierre,RIPOCHE, Sebastien,LIAO, Lv,XIONG, Jing,ZHAO, Xianglin,HAN, Bo,WANG, Can
申请号：
ES14806081
公开号：
ES2682493T3
申请日:
2014.10.24
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of the formula (i) or a pharmaceutically acceptable Salt of the same * * * * formula where V is selected from CH2, CH (OH) W is selected from CH2,Ch2ch2 link X is C (RX) or N and C (ry) or N Z is CH or N where X N and Z n, and are not where and when it is n, X and Z are not when z is n, where n,X and y are not n, RX is selected from Hydrogen, halogen, haloalquilo C1 - C3 alkyl, cyano, C1 - C6, hidroxialquilo C1 - C6 ry is selected from Hydrogen, halogen, alquiloc1 - C3Hidroxialcoxiloc1 - alkoxyl - C6 C1, C3, nry1ry2, cyano, alcoxiloc1 c3alcoxiloc1 - - - - alcoxiloc1 C3, C3 (C3 haloalcoxiloc1 -, di - aminoalcoxiloc1 alquiloc1 C3 C6) - or - (CH2) 0 - 1 - RY3, cry6ry7 alquiloc1 C3 -, S -,Haloalcoxilo C1 - C6 optionally substituted by hydroxyl or RX and Ry together with the fixed Ring which forms a bicyclic Aromatic Ring System optionally includes one orTwo heteroatoms selected from N, o, S, such a Ring system is optionally substituted by alkyl C1 - C3 RY1 is Hydrogen and RY2 is selected from alquiloc1 - hidroxialquiloc1 - C6 C6Haloalquilo C1 - C6 optionally substituted by hydroxyl alcoxiloc1 - c4alquiloc1 - C6 haloalcoxiloc1 - c3alquilo C1 - C6 (CH2) 0 - 1 - RY4, di (alquiloc1 - C3) aminoalquiloc1 - C6 substituted by hydroxylBicyclo - alquiloc5 - 8 replaced by hidroxialquilo C1 - C3PHENYL substituted by S (OR) 2 - ch (CH3) 2 \u00e1cidoc2 - C3 alquilsulf\u00f3nico or RY1 and RY2 together with the N Atom which are fixed to form a six member Heterocyclic ring aromatic saturated and not saturatedOr it may contain an Atom or Ring can be replaced, perhaps once or twice per ry5 RY3 is selected from benzilate, a Heterocyclic Ring 4,5 - or 6 saturated Member comprising at least one heteroatom selected from N, o or s, or a Heterocyclic Aromatic Ring of 5 or 6 members.Which is saturated or Aromatic Heterocyclic ring is optionally substituted by alkyl and \/ or C1 - C3 oxo RY4 is a Heterocyclic Ring 4,5 - or 6 - saturated Member comprising at least one heteroatom select
