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Modulators of LXR
专利权人:
Exelixis Patent Company LLC;Bristol-Myers Squibb Company
发明人:
KICK, Ellen,BODAS, Mandar,MOHAN, Raju,BUSCH, Brett,AVERBUJ, Claudia,VALENTE, Meriah,WURTZ, Nicholas,RAO, Prasanna Savanor,SHETTY, Jeevanprakash,VENU, Alla,KICK ELLEN,BODAS MANDAR,MOHAN RAJU,BUSCH BRETT,AVERBUJ CLAUDIA,VALENTE MERIAH,WURTZ NICHOLAS,RAO, Pr
申请号:
ES14770510
公开号:
ES2694001T3
申请日:
2014.03.14
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of formula I or II, ** Formula ** or a pharmaceutically acceptable salt or solvate thereof, wherein Ring C is selected from oxazolyl and triazolyl; Ring D is selected from phenyl and pyridyl; A is phenyl or a 5- or 6-membered heteroaryl, wherein the phenyl is optionally fused to a 5- or 6-membered heterocyclyl or 5- or 6-membered heteroaryl, wherein A is optionally substituted with 1, 2 or 3 RA groups, wherein each RA is independently RA1, -C1-C6 alkyl-RA1, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, pyrrolidinone or pyrrolidinyl, wherein the cycloalkyl is optionally substituted with 1, 2, 3 or 4 groups which are independently RA1, C1-C6 alkyl or-C1-C6 alkyl-RA1, wherein each RA1 is independently halogen, cyano, nitro, -OR, -NR2, -SR, -C (O) R or -C (O) OR; alternatively, two RAs in adjacent carbons can be joined to form an -O-CH2-O-, -O-CH2-CH2-, -O-CH2-CH2-O-, -CH2-CH2-CH2- or -O- CF2-O-; RB1 is hydrogen, C1-3 alkyl, halo, cyclopropyl, or C1-3 haloalkyl; RB2 is hydrogen, halo, -CN, -C (O) NR2, or C1-3 alkyl; RB3 is C1-6 alkyl, C1-6 haloalkyl, or C3-6 cycloalkyl, each of which is substituted with 0-1 RB5; hydrogen; cyano; -C (O) -R; -C (O) NR2; -NHC (O) R; -NHSO2R; or a 5-membered ring heteroaryl, wherein the heteroaryl ring consists of carbon atoms and 1, 2 or 3 heteroatoms independently selected from the group consisting of N, S and O and is substituted with 0-1 R; RB4 is H, halogen, C1-3 alkyl, C1-3 haloalkyl, -C3-C6 cycloalkyl, or -O-C1-3 alkyl; RB5 is cyano, -OR, -C (O) NR2, -C (O) OR, -NR2, -OC (O) -NH2, -S (O) 2NR2, or a 5-membered ring heteroaryl, wherein the heteroaryl ring consists of carbon atoms and 1, 2 or 3 heteroatoms independently selected from the group consisting of N, S and O; R is hydrogen, halogen, cyano or nitro; n is 0, 1, 2, 3 or 4; and each RD1 and RD2 are independently RD3, C1-C6 alkyl, -C1-C6-RD3 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, or C3-C8 cycloalkyl, wherein the cycloalkyl i
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