HALLYM UNIVERSITY;INDUSTRY ACADEMIC COOPERATION FOUNDATION
发明人:
JUN, JONG GAB,전종갑,HYEONG JIN PARK,박형진,JUN, JONG GABKR
申请号：
KR1020180036560
公开号：
KR1019975160000B1
申请日:
2018.03.29
申请国别(地区):
KR
年份:
2019
代理人:
摘要：
An object of the present invention is to provide an anti-inflammation agent having excellent efficacy and minimized side effects by solving side effects of existing anti-inflammation agents, and to provide a novel nocarbenzoxazole derivative and a synthesis method thereof. By using a POCl_3-mediated ring dehydration reaction using commercially available inexpensive raw materials and selective and/or complete demethylation and a reduction reaction as main reactions, nocarbenzoxazole derivatives are easily synthesized in a 15 to 49% of yield and it is confirmed by testing anti-inflammatory activity of compounds.과제: 종래 항염증제의 부작용을 해결하여 효능이 우수하고 부작용을 최소화한 항염증제를 제공하는 것, 새로운 노카벤즈옥사졸 유도체 및 그 합성방법을 제공하는 것.과제의 해결 수단: 상업적으로 판매하는 저렴한 원료물질을 이용하여 POCl3-매개 원환탈수반응, 선택적 및/또는 완전한 탈메틸화 및 환원반응을 주요 반응으로 하여 15~49% 수율로 노카벤즈옥사졸 F 및 노카벤즈옥사졸 유도체를 손쉽게 합성하였고, 이 화합물들의 항염증 활성을 시험하여 입증하였다.
