Jean Bernadou,Vania Bernardes-Genisson,Tamara Delaine,Annaïck Quemard
申请号：
US12866645
公开号：
US08710073B2
申请日:
2009.02.06
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to bi-substrate inhibitor molecules combining (i) a pyridine, pyridinium or dihydropyridine-type structure allied to active metabolites of isoniazide, or related structures, and (ii) a hydrophobic substituent. The invention also relates to the method for preparing said molecules, to the pharmaceutical compositions containing said molecules, and to the use thereof as inhibitors of enoyl reductase for the preparation of a drug, especially an anti-infective drug for the treatment of tuberculosis.
