An ophthalmic surgical cassette for collecting aspirant fluid and/or tissue during an ophthalmic surgical procedure. The ophthalmic surgical cassette includes a rigid walled container having an interior volume for collecting aspirant fluid and/or tissue and an aspiration manifold coupled to the rigid walled container. The aspiration manifold is connected to an aspiration tube in fluidic communication with the interior volume, a first aspiration line for coupling a first surgical handpiece, a second aspiration line for coupling a second surgical handpiece, and a reflux bulb in fluidic communication with the first and second aspiration lines.
