The present invention discloses a pharmaceutical composition to rapidly increase a content and an availability of a cyclic adenosine monophosphate (cAMP) in a body, including: ginsenosides Rg1, Rb1 and Re, a glycyrrhiza related acid being one selected from a group consisting of a glycyrrhizic acid, a glycyrrhetinic acid and a combination thereof, and a jujuba cyclic adenosine monophosphate (jujuba cAMP).