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Cyclohexane-1,2′-naphthalene-1′,2″-imidazol compounds and their use as BACE inhibitors
专利权人:
发明人:
Sofia Karlstrom,Lars Sandberg,Peter Soderman,Karin Kolmodin,Liselotte Ohberg
申请号:
US13916731
公开号:
US09000184B2
申请日:
2013.06.13
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Cyclohexane-1,2′-naphthalene-1′,2″-imidazole compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of such compounds for treating Aβ-related pathologies such as Downs syndrome, β-amyloid angiopathy, Alzheimers disease, memory loss, attention deficit symptoms associated with Alzheimers disease, neurodegeneration associated with diseases such as Alzheimers disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinsons disease, progressive supranuclear palsy or cortical basal degeneration, methods of therapy using such compounds, and pharmaceutical compositions containing such compounds.
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