AHN, KYOUNG JIN,안경진,MOON, SEONG CHEOL,문성철,JUNG, HO KYOUNG,정호경,LEE, SEOK CHEOL,이석철,LEE, JAE IL,이재일,LEE, IN HYE,이인혜,KIM, BYEONG JIN,김병진,HWANG, EUN JU,황은주,AHN, KYOUNG JINKR,MOON, SEONG CHEOLKR,JUNG, HO KYOUNGKR,LEE, SEOK CHEOLKR,LEE, JAE ILKR,LEE, IN HYEKR,KIM, BYEONG JINKR,HWANG, EUN JUKR
申请号：
KR1020170051707
公开号：
KR1019125250000B1
申请日:
2017.04.21
申请国别(地区):
KR
年份:
2018
代理人:
摘要：
The present invention relates to a manufacturing method of an oral preparation coated with calcium chloride and levan. The oral preparation coats a target material supported on an alginic acid with calcium chloride and levan. According to the present invention, probiotics such as lactobacillus in which activity is easily inhibited due to various drugs and stomach acids, which are prevented from being absorbed in a gastrointestinal, are emitted in a small intestine, thereby manufacturing the oral preparation having excellent selective drug transmissibility. The manufacturing method comprises: a first step of preparing an alginic acid solution, a calcium chloride solution and a levan solution on which the target material is supported； a second step of mixing the calcium chloride solution and the levan solution to manufacture a coating solution, and dropping the alginic acid solution on which the target material is supported to the coating solution； and a third step of collecting and drying a coating preparation generated by reacting the alginic acid solution with the coating solution through the dropping method.본 발명은 염화칼슘 및 레반으로 코팅한 경구용 제제의 제조방법에 관한 것으로서, 상기 경구형 제제는 알긴산에 담지된 타겟물질을 염화칼슘 및 레반으로 코팅한 것이다. 본 발명을 통해 위장에서 흡수를 피해야 하는 각종 약물, 위산으로 인해 쉽게 활성이 저해되었던 유산균 등의 생균제가 소장 내에서 방출되는 효과를 야기함으로써 선택적 약물 전달성이 뛰어난 경구용 제제를 제조가 가능하다.
