The methods disclosed herein can be used in the manufacture of a controlled release composition. The method provides the creation of a controlled release composition containing a bioactive agent, is brought into contact with an aqueous phase containing an organic ion, an organic phase containing a polymer and a bioactive agent in particular. The present invention also includes a controlled release composition of the bioactive agent-containing polymer, an organic ion. The invention also includes the use of controlled release such compositions further. Utility of the present invention is that containing a bioactive agent, the production of controlled release compositions which can be administered by small volume of concentrated dosage form is made by the present method, the composition, the bioactive agent decomposition product generation of biologically active substances and initial burst release is reduced.本明細書において開示される方法は、制御放出組成物の製造に用いられる。特に本方法は、生物活性因子とポリマーを含む有機相を、有機イオン含有の水相に接触させて生物活性因子含有の制御放出組成物の創成を提供する。また本発明は、ポリマー、有機イオンと生物活性因子含有の制御放出組成物も含む。さらに本発明はそのような制御放出組成物の使用法も含む。本発明の有用性は、生物活性因子を含み、濃縮化小容量剤型による投与が可能な制御放出組成物の製造が本方法によって成されることであり、その組成物は、生物活性因子の初期急激放出及び生物活性物質の分解物生成が減少する。