The methods disclosed herein are of use for the production of controlledrelease compositions. In particular, the methods provide the contacting of anorganic phase containing a bioactive agent and a polymer with an aqueous phasecontaining an organic ion to create controlled release compositions containingbioactive agents. The present invention also includes controlled releasecompositions including a polymer, an organic ion and a bioactive agent. Thepresent invention also includes methods of using such controlled releasecompositions. The usefulness of the present invention is that the methodsresult in the production of controlled release compositions containingbioactive agent capable of administration in a concentrated low-dose form,having low burst and reduced production of degraded bioactive agent.
