CHOI, YOUNG KWEON,최영권,HONG, DONG HYUN,홍동현,KIM, SEONG SOO,김성수,CHOI, YOUNG KWEONKR,HONG, DONG HYUNKR,KIM, SEONG SOOKR
申请号：
KR1020150181809
公开号：
KR1020160074433A
申请日:
2015.12.18
申请国别(地区):
KR
年份:
2016
代理人:
摘要：
The present invention relates to a transdermal absorption preparation for treating dementia, comprising donepezil as an active ingredient. The transdermal absorption preparation of the present invention comprising donepezil with high concentrations inside a hydrophobic matrix has excellent skin adhesion for a long period of time, and can continuously release drugs for a long period of time. In addition, the transdermal absorption preparation of the present invention has a skin penetration rate significantly more increased than that of the existing donepezil patch agent, and continuously exhibits effective treatment effects for a long period of time. The transdermal absorption preparation comprises: (a) a supporting layer； (b) a drug-containing matrix layer； (c) a polymer adhesive matrix layer； and (d) a delamination layer.본 발명은 도네페질을 유효성분으로 함유하는 치매치료용 경피흡수제제에 관한 것으로, 본 발명의 경피흡수제제는 소수성 매트릭스 내에서 고농도의 도네페질을 함유하고 장기간의 피부 부착성이 우수하여 장기간 약물을 지속적으로 방출할 수 있을 뿐만 아니라, 피부투과속도가 기존의 도네페질 패치제보다 현저하게 향상되어 장기간에 걸쳐 지속적으로 유효한 치료 효과를 나타낸다.
