Aminoalcohol derivatives (I) are new. Aminoalcohol derivatives of formula (I) and their salts and esters are new. [Image] R 1, R 2H, lower alkyl or amino protecting group； R 3H, lower alkyl or hydroxy protecting group； R 4lower alkyl； n : 1-6； X : O or ND； D : H, Ar, SO 2-lower alkyl, SO 2Ar or A； Y : ethylene, vinylene, ethynylene, ECH 2 or 6-10C arylene (optionally substituted by 1-3 A)； E : CO or CHOH； Z : bond or 1-10C alkylene optionally substituted by 1-3 A or B and optionally interrupted by O or S； R 5H, 3-10C cycloalkyl, Ar or 5-7 membered heterocyclyl containing 1-3 O, N and/or S all optionally substituted by 1-3 A or B； R 6, R 7H or A； A : halo, lower alkyl, lower haloalkyl, O-lower alkyl, S-lower alkyl, COOH, COO-lower alkyl, OH, lower aliphatic acyl, NH 2, NH-lower alkyl, N(lower alkyl) 2, lower aliphatic acylamino, CN or NO 2； and B : 3-10C cycloalkyl, Ar or 5-7 membered heterocyclyl containing 1-3 O, N and/or S all optionally substituted by 1-3 A； provided that when R 5 = H then Z is not a bond or linear 1-10C alkylene. ACTIVITY : Immunosuppressive； Dermatological； Antiarthritic； Antirheumatic； Antiinflammatory； Osteopathic； Vasotropic； Gastrointestinal-Gen.； Antiulcer； Hepatotropic； Cardiovascular-Gen.； Respiratory-Gen.； Antiasthmatic； Cardiant； Nephrotropic； Hypotensive； Neuroprotective； Antidiabetic； Antiarteriosclerotic； Muscular-Gen.； Virucide； Antianginal； Antiaggregant； Thrombolytic； CNS-Gen.； Nootropic； Antiparkinsonian； Antidepressant； Anticonvulsant； Cytostatic； Uropathic； Ophthalmological. In a graft versus host reaction model using Lewis and WKAH/Hkm rats administration of 2-amino-2-methyl-5-[5-(5-phenylpentanoyl)thien-2-yl]butan-1-ol (Ia) maleic acid salt (0.008 mg/kg/day p.o.) inhibited host versus graft reaction by 16.0 %. The corresponding value for a combination of (Ia) maleic acid salt (0.008 mg/kg/day p.o.) and cyclosporin A (0.08 mg/kg/day p.o.) was 36.1 % and for cyclosporin A (0.08 mg/kg/day p.o.) was 18.7 %. MECHANISM OF ACTION :
