БЭЙЛЗ Брайан Кристофер (US),ГРИММОНД Брайан Джеймс (US),МЕЙЕР Дэниел Юджин (US),ХЭЙ Брюс Аллан (US),ЛАТТРЕЛ Майкл Тодд (US)
申请号：
RU2014149664
公开号：
RU2014149664A
申请日:
2013.06.27
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A process comprising the steps of: a) cleaning composition to produce a purified composition, wherein the purified composition comprises at least one nanoparticle, which is in a liquid carrier, wherein the nanoparticle comprises a core and a cladding bonded to the core, wherein the shell comprises a plurality of ligands, b) adding an amount of aggregate to treated ligand composition to form the drug, wherein at least part of the additive amount of the ligand remains attached to the core and c) sterilizing preparata.2. A method according to Claim. 1, wherein the shell ligands and ligands were added to the purified composition are structurally identichnymi.3. A method according to Claim. 1, where the drug is sterilized by heat sterilizatsii.4. A method according to Claim. 1 where the preparation is sterilized by avtoklavirovaniya.5. A method according to Claim. 1, wherein the core comprises oxides of tungsten, tantalum, hafnium, zirconium, zinc, molybdenum, silver, iron, manganese, copper, cobalt, nickel, or combinations of two or more of said oxides of transition metallov.6. A method according to Claim. 1, wherein the core comprises a paramagnetic metal comprising iron, manganese, copper, cobalt, nickel or their kombinatsii.7. A method according to Claim. 1, wherein the core comprises a superparamagnetic zheleza.8 oxide. A method according to Claim. 1, where the plurality of ligands include phosphate, phosphonate or kombinatsiyu.9. A method according to claim. 8, which includes a plurality of ligands monophosphate phosphate, hydrogen phosphate, polyphosphate or kombinatsiyu.10. A method according to claim. 8, which includes a plurality of phosphonate ligands monophosphonate, alpha-hydroxy phosphonates, bisphosphonate or polyphosphonate kombinatsiyu.11. A method according to claim. 8, where the set of ligands also contains polyethylene glycol (PEG) functional gruppu.12. A method according to Claim. 1, where the totality1. Способ, включающий стадии:а) очистки композ
