The present invention relates to pharmaceutical compositions for oral delivery comprising at least two bioactive proteins associated with glucose metabolism selected from the group consisting of insulin proinsulin and C Peptide in a delivery vehicle adapted for oral administration that provides portal delivery of bioactive proteins. The exemplary pharmaceutical compositions comprise an oil based matrix comprising solid particulate matter suspended therein wherein the particulate matter comprises a polysaccharide non covalently associated with silica particles having a hydrophobic surface wherein the polysaccharide and silica particles are non covalently associated with the at least two bioactive proteins. The present invention further provides therapeutic uses of said pharmaceutical compositions.
