METHOD FOR THE SELECTION OF ANTIBODIES AGAINST BCMA

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专利权人:

ENGMAB SARL

发明人:

Minh Diem VU,Klaus STREIN,Ekkehard MOESSNER,Ralf HOSSE,Oliver AST,Anne FREIMOSER-GRUNDSCHOBER,Marina BACAC,Tanja FAUTI,Christian KLEIN,Pablo UMANA,Samuel Moser

申请号：

US15945554

公开号：

US20180222991A1

申请日:

2018.04.04

申请国别(地区):

US

年份:

2018

代理人:

摘要：

An antibody specifically binding to human BCMA, characterized in that the binding of said antibody is not reduced by APRIL and not reduced by BAFF, said antibody does not alter APRIL-dependent NF-κB activation, BAFF-dependent NF-κB activation, and does not alter NF-κB activation without BAFF and APRIL is useful as a therapeutic agent.

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