Method for the selection of antibodies against BCMA

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专利权人:

ENGMAB AG

发明人:

Minh Diem Vu,Klaus Strein,Ekkehard Moessner,Ralf Hosse,Oliver Ast,Anne Freimoser-Grundschober,Marina Bacac,Tanja Fauti,Christian Klein,Pablo Umana,Samuel Moser

申请号：

US14764967

公开号：

US09963513B2

申请日:

2014.02.05

申请国别(地区):

US

年份:

2018

代理人:

摘要：

An antibody specifically binding to human BCMA, characterized in that the binding of said antibody is not reduced by APRIL and not reduced by BAFF, said antibody does not alter APRIL-dependent NF-κB activation, BAFF-dependent NF-κB activation, and does not alter NF-κB activation without BAFF and APRIL is useful as a therapeutic agent.

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