您的位置: 首页 > 农业专利 > 详情页

COMBINED PRODUCTS CONTAINING TYROZINKINASE INHIBITORS AND THEIR APPLICATION
专利权人:
НОВАРТИС АГ (CH)
发明人:
ТИДТ Ральф (CH),ШАТЕНЕ-РИВОДЕ Кристиан (CH),ИТО Морико (CH),ПЭН Бинь (CN),ГУН Ин (CN),АКИМОВ Михаил (CH)
申请号:
RU2014144254
公开号:
RU2014144254A
申请日:
2013.04.03
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A pharmaceutical combination comprising (i) a MET tyrosine kinase inhibitor and (ii) an EGFR tyrosine kinase inhibitor, or a pharmaceutically acceptable salt thereof, respectively, or a prodrug thereof, respectively, and at least one pharmaceutically acceptable carrier. A pharmaceutical combination according to claim 1 for the simultaneous, separate or sequential use of components (i) and (ii). 3. The pharmaceutical combination of claim 1 in the form of a fixed combination. The pharmaceutical combination of claim 1 in the form of a dosage form or in a kit consisting of parts for combined administration, wherein the EGFR tyrosine kinase inhibitor and MET tyrosine kinase inhibitor can be administered independently at the same time or separately at time intervals, in particular if the indicated time intervals make possible the joint activity of the participants in the combination. 5. The pharmaceutical combination according to any one of paragraphs. 1-4, where the EGFR tyrosine kinase inhibitor is erlotinib, gefitinib, lapatinib, canterinib, pelitinib, neratinib or cetuximab; and where the MET inhibitor is a compound of the formula: or a pharmaceutically acceptable salt or prodrug thereof, respectively. The combination according to claim 1, containing an additional coagent or a pharmaceutically acceptable salt or prodrug thereof. The combination according to claim 1, comprising an amount that is jointly therapeutically effective against a disease mediated by the tyrosine kinase activity of EGFR and / or tyrosine kinase activity of MET, in particular a malignant tumor, comprising as participants in the combination (i) an EGFR tyrosine kinase inhibitor and (ii) an inhibitor tyrosine kinases MET, or, accordingly, their pharmaceutical1. Фармацевтическая комбинация, содержащая (i) ингибитор тирозинкиназы МЕТ и (ii) ингибитор тирозинкиназы EGFR, или его фармацевтически приемлемую соль, соответственно, или его пролекарство, соответственно, и, по меньшей мере, один фармацев
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充