University of Pittsburgh - Of the Commonwealth System of Higher Education
发明人:
KLUNK, WILLIAM E.,MATHIS, JR. CHESTER A.
申请号：
PL06825654
公开号：
PL1945622T3
申请日:
2006.10.10
申请国别(地区):
PL
年份:
2012
代理人:
摘要：
Benzofuran compounds which contain at least one detectable label selected from the group consisting of 131I, 123I, 124I, 125I, 76Br, 75Br, 18F, 19F, 11C, 13C, 14C and 3H are provided as amyloid imaging agents for detecting brain amyloid deposits as well as other amyloidogenic peptides associated with systemic or localized amyloidosis. Additionally, the compounds are useful for determining if patients, presenting with clinically confusing cases of dementia or presenting with mild cognitive impairment, have Alzheimer's disease. The compounds are additionally useful as surrogate markers for monitoring the efficacy of anti-amyloidosis therapies.
