Nicolau, Claude,Greferath, Ruth,Hickman, David,Pfeifer, Andrea,Muhs, Andreas
申请号：
AU2012244075
公开号：
AU2012244075A1
申请日:
2012.10.19
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2012244075A120121115.pdf#####ABSTRACT The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimers disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of p-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimers Disease (AD).WO 2007/068412 PCT/EP2006/011862 6/6 Measured spectrum - Sum of fits Fit of Val CO -sheet Fit of Val CO -random 70 60 50 40 30 20 10 1C Chemical Shift (ppm) -Measured spectrum -- Sum of fits - Fit of Val Cp -sheet - Fit of Val CP -random 70 60 50 40 30 20 10 1C Chemical Shift (ppm) ---- --- Fit for -sheet of 13C-labeled Val12 ". Fit for random-coiled of 13C-labeled Val12 FIG. 4
