N-(3-HÉTÉROARYLARYL)-4-ARYLARYLCARBOXAMIDES ET ANALOGUES COMME INHIBITEURS DE LA VOIE HEDGEHOG ET LEUR UTILISATION

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专利权人:

IMPACT THERAPEUTICS; INC.

发明人:

CAI, SUIXIONG,TIAN, YE EDWARD,KANG, SISHUN,MENG, ZHENG,GU, CHENGYUN,YIN, FENG,CHEN, SHENGZHI,ZHANG, YANG,ZHANG, XIUYAN,FEI, HONGQIANG,WANG, DONGMEI

申请号：

EP13819949

公开号：

EP2875005A4

申请日:

2013.07.19

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

Disclosed are novel N-(3-heteroarylaryl)-4-arylarylcarboxamides and analogs thereof, represented by the Formula I: wherein C cyclic group, D1-D4, Q1, Q2, R5 are defined herein. Compounds having Formula (I) are hedgehog pathway inhibitors. Therefore, compounds of the invention may be used to treat clinical conditions that are responsive to the inhibition of hedgehog activity, such as cancer.

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