The present invention relates to an urea-substituted aromatic ring-linked dioxazoline compound of formula (I), a pharmaceutically acceptable salt or hydrate thereof. The invention also provides a preparation method of the compound of formula (I) and a pharmaceutically acceptable salt thereof, as well as uses thereof as a drug, wherein the drug acting as a tyrosine kinase (i.e. VEGFR -2, C-RAF, B-RAF, and RET) inhibitor is used for treating disorders related to tyrosine kinase.