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SOLID COMPOSITION FOR ORAL ADMINISTRATION OF DYES AND THEIR DIAGNOSTIC USE
专利权人:
КОСМО ТЕКНОЛОДЖИЗ ЛТД. (IE)
发明人:
МОРО Луиджи (IT),АЯНИ Мауро Северино (IT),ВИЛЛА Роберто (IT),ЧЕЛАСКО Джузеппе (IT),РЕПИЧИ Алессандро (IT)
申请号:
RU2012142192/15
公开号:
RU2012142192A
申请日:
2011.03.02
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. Solid composition for oral administration containing at least one dye in combination with at least one physiologically acceptable excipient, characterized in that it contains: a) a matrix, which consists of lipophilic compounds with a melting point below 90 ° C and amphiphilic compounds in which at least partially included said at least one dye; b) an outer matrix, which consists of hydrophilic compounds in which a lipophilic matrix and an amphiphilic matrix are dispersed; c) optionally, other physiologically acceptable excipients; d) optionally stable gastric juice coating, wherein said at least one dye is selected from methylene blue, Congo red, indigo carmine, toluidine blue, or mixtures thereof. 2. The composition of claim 1, wherein said at least one colorant is present in an amount of 2 mg to 1000 mg. A composition according to claim 2, wherein said at least one colorant is present in an amount of 10 mg to 1500 mg. The composition of claim 3, wherein said at least one colorant is present in an amount of 50 mg to 1200 mg. The composition of claim 2, wherein said at least one colorant is present in an amount of 20 mg to 500 mg. The composition of claim 1, wherein said at least one colorant is present in an amount equivalent to about 25 mg. The composition of claim 1, wherein said at least one colorant is present in an amount equivalent to about 50 mg. Composition according to claim 1 in the form of a tablet or capsule. The composition according to claim 1, in which said lipophilic compounds are selected from saturated, n1. Твердая композиция для перорального введения, содержащая по меньшей мере один краситель в сочетании с по меньшей мере одним физиологически приемлемым эксципиентом, отличающаяся тем, что она содержит:a) матрицу, которая состоит из липофильных соединений с точкой плавления ниже 90°C и амфифильных соединений, в которые по меньшей мере частично включен указанный по меньшей мере один краситель;b) наружную матрицу, которая состоит из гидрофильных
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