CESATI, RICHARD R.,塞萨堤 理查Ｒ,塞薩堤 理查Ｒ,CHEESEMAN, EDWARD H.,却士曼 艾德华Ｈ,卻士曼 艾德華Ｈ,LAZEWATSKY, JOEL,莱兹瓦司基 乔尔,萊茲瓦司基 喬爾,RADEKE, HEIKE S.,瑞德克 海克Ｓ,瑞德克 海克Ｓ,CASTNER, JAMES F.,凯斯纳 詹姆士Ｆ,凱斯納 詹姆士Ｆ,MONGEAU, ENRICO,孟乔 安力可
申请号：
TW106115472
公开号：
TWI664169B
申请日:
2011.02.08
申请国别(地区):
TW
年份:
2019
代理人:
摘要：
The present invention generally relates to methods and system for the synthesis of imaging agents, and precursors thereof. The methods may exhibit improved yields and may allow for the large-scale synthesis of imaging agents, including imaging agents comprising a radioisotope (e.g.,18F). Various embodiments of the invention may be useful as sensors, diagnostic tools, and the like. In some cases, methods for evaluating perfusion, including myocardial perfusion, are provided. Synthetic methods of the invention have also been incorporated into an automated synthesis unit to prepare and purify imaging agents that comprise a radioisotope. In some embodiments, the present invention provides a novel methods and systems comprising imaging agent 1, including methods of imaging in a subject comprising administering a composition comprising imaging agent 1 to a subject by injection, infusion, or any other known method, and imaging the area of the subject wherein the event of interest is located.本發明大體上關於合成造影劑及其前驅體之方法及系統。該等方法可呈現改良產率且可允許大規模合成造影劑，包括該等包含放射性同位素(例如18F)之造影劑。本發明之多種實施例可用作感測器、診斷工具及其類似物。在一些情況下，提供用於評估灌注(包括心肌灌注)之方法。本發明之合成方法亦可併入自動合成單元中以製備及純化包含放射性同位素之造影劑。在一些實施例中，本發明提供包含造影劑1之新穎方法及系統，包括在個體中造影之方法，該方法包含藉由注射、輸注或任何其他已知方法向個體投與包含造影劑1之組合物，及對該個體中相關事件所定位之區域造影。
