Lily Lee Searle;Dionisois Rentzeperis;Raymond Patch;Michael Gaul;Xizhen Zhu;Guozhang Xu;Alexander Kim
发明人:
Michael Gaul,Alexander Kim,Lily Lee Searle,Raymond Patch,Dionisois Rentzeperis,Guozhang Xu,Xizhen Zhu
申请号：
US12899812
公开号：
US08344009B2
申请日:
2010.10.07
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to compounds of Formula (I),methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.
