PROBLEM TO BE SOLVED: To provide a device for improving injection efficiency and discharge efficiency with an ultrasonic amplitude and current introduction as low as possible, even while conventionally a method for opening a cavitation hole on a surface of an object to be an introduction target by a strong ultrasonic amplitude and improving introduction efficiency through the mechanically damaged hole is proposed for the improvement of drug introduction efficiency by the use of both of an ultrasonic introduction method and an ion introduction method, since a body surface or the like is damaged in this case, active hydrogen and alkali salt are formed near an electrode and active oxygen or the like is formed at a counter electrode by the excessive current of a DC voltage, an AC voltage and an asymmetric pulse voltage further, and the body surface or the like, which is an introduction target object, is mechanically and chemically damaged.SOLUTION: The electric introduction method of an ionization drug is combined with an "ultrasonic drug injection device" using the weak ultrasonic amplitude, a half wave rectification ion introduction voltage of 90-degree lag phase synchronization from an ultrasonic driving voltage is loaded between the counter electrodes provided on a part of the body together with a vibration amplitude from a vibrator surface, and weak-current and high-efficiency introduction is made possible by superimposition with ultrasonic distortion amplitude.COPYRIGHT: (C)2012,JPO&INPIT【課題】従来超音波導入法とイオン導入法併用による薬物導入効率向上は強超音波振幅によって、導入目的とする物体の表面にキャビテーション孔を開け、機械的に傷ついたこの穴を通し導入効率を上げる方法が提案されている。しかしながら、この場合は体表面等が傷つけられ、更に直流電圧、交流電圧、非対称パルス電圧の過剰な電流により電極近傍に活性水素やアルカリ塩、対極には活性酸素等が作られ、被導入物体である体表等を機械的、化学的に傷つけるので可能な限り低超音波振幅で、且つ低電流導入が求められる。【解決手段】弱超音波振幅を使う「超音波薬物注入装置」にイオン化薬物の電気導入法を組み合わせ、超音波駆動電圧と90度遅れ位相同期の半波整流イオン導入電圧を振動子面から振動振幅と供に身体の一部に設けた対極間に負荷し、超音波歪振幅との重畳により弱電流高効率導入を可能にする。【選択図】 図1
