The present invention addresses the problem of providing chimeric antigen receptor (CAR)-expressing T cells that express a CAR and also express a T cell immunological function promoting factor, and that have a strong immunity-inducing effect and high antitumor activity. The present invention also addresses the problem of providing a CAR expression vector for producing such CAR-expressing T cells. This CAR expression vector contains a nucleic acid that codes for a CAR, and a nucleic acid that codes for a T cell immunological function promoting factor, wherein the nucleic acid that codes for the T cell immunological function promoting factor comprises either: the nucleic acid that codes for interleukin-7 and the nucleic acid that codes for CCL19； a nucleic acid that codes for a dominant-negative mutant of SHP-1； or a nucleic acid that codes for a dominant-negative mutant of SHP-2. CAR-expressing T cells into which said CAR expression vector has been introduced are produced.本發明之課題係在於，提供一種在T細胞中與嵌合抗原受體(CAR)一同表現T細胞之免疫功能存進因子，且免疫誘導效果和抗腫瘤活性高的CAR表現T細胞、和用於製造該CAR表現T細胞之CAR表現載體。本發明製造CAR表現載體、和導入了所述CAR表現載體的CAR表現T細胞，該CAR表現載體含有編碼嵌合抗原受體(CAR)的核酸和編碼T細胞之免疫功能促進因子的核酸，其中，所述編碼免疫功能促進因子的核酸為編碼介白素7的核酸和編碼CCL19的核酸、編碼相對於SHP-1的顯性失活突變體的核酸、或者編碼相對於SHP-2的顯性失活突變體的核酸。
