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Car expression vector and car-expressing t cells
专利权人:
YAMAGUCHI UNIVERSITY
发明人:
Tamada, Koji,Sakoda, Yukimi,Adachi, Keishi
申请号:
NZ73038215
公开号:
NZ730382A
申请日:
2015.10.06
申请国别(地区):
NZ
年份:
2019
代理人:
摘要:
The present invention desirably provides CAR-expressing T cells that coexpress a chimeric antigen receptor (CAR) and a T cell immune function-enhancing factor and have a high immunity-inducing effect and antitumor activity, and desirably provides a CAR expression vector for the preparation of the CAR-expressing T cells. The CAR expression vector comprises a nucleic acid encoding a chimeric antigen receptor (CAR) and a nucleic acid encoding a T cell immune function-enhancing factor, wherein the nucleic acid encoding an immune function-enhancing factor is a nucleic acid encoding interleukin-7 and a nucleic acid encoding CCL19. The CAR may comprise a single chain antibody that recognizes a cell surface antigen on a cancer cell, a transmembrane region, and a signal transduction region that induces the activation of a T cell.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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