צימודים חיסוניים של נוגדן אנטי-pd-1 עם מוטציית il-2 או il-15

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专利权人:

F. HOFFMANN-LA ROCHE AG

发明人:

申请号：

IL26939519

公开号：

IL269395D0

申请日:

2019.09.16

申请国别(地区):

IL

年份:

2019

代理人:

摘要：

The present invention generally relates to immunoconjugates, particularly immunoconjugates comprising a mutant interleukin-2 polypeptide and an antibody that binds to PD-1. In addition, the invention relates to polynucleotide molecules encoding the immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.

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