Laura Codarri Deak,Christian Klein,Laura Lauener,Valeria G. Nicolini,Stefan Seeber,Pablo Umana,Inja Waldhauer
申请号：
US15943237
公开号：
US20180326010A1
申请日:
2018.04.02
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention generally relates to immunoconjugates, particularly immunoconjugates comprising a mutant interleukin-2 polypeptide and an antibody that binds to PD-1. In addition, the invention relates to polynucleotide molecules encoding the immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
