AST, Oliver,Bruenker, Peter,FREIMOSER-GRUNDSCHOBER, Anne,HERTER, Sylvia,Hofer, Thomas U.,HOSSE, Ralf,KLEIN, Christian,MOESSNER, Ekkehard,Nicolini, Valeria G.,Umana, Pablo
申请号：
DK16164244
公开号：
DK3075745T3
申请日:
2012.02.07
申请国别(地区):
DK
年份:
2018
代理人:
摘要：
The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the ±-subunit of the IL-2 receptor, for use as immunotherapeutic agents. In addition, the invention relates to immunoconjugates comprising said mutant IL-2 polypeptides, polynucleotide molecules encoding the mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
